DRUG TRIALS

prescription-drug-bottlesMany people are very carefree when it comes to taking drugs.

  • Then there are people that read every side effect and soon it is projected into their existence …
  • Just for the fun of it I googled the list of possible side effects for a popular drug that several people I know take regularly…

Have you ever stopped to think about the numbers of people tested to allow new drugs to come into our lives?

Side effects of a very common drug….

More Common

  • Sleepiness or unusual drowsiness

Less Common

  • Abdominal or stomach pain
  • abnormal or decreased touch sensation
  • abnormal sensation of movement
  • appetite disorder
  • balance disorder
  • binge eating
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • change in hearing
  • chest discomfort
  • chills
  • confusion about identity, place, and time
  • constipation
  • continuous ringing, buzzing, or other unexplained noise in the ears
  • daytime drowsiness
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty with moving
  • difficulty with swallowing
  • discouragement
  • double vision
  • drugged feeling
  • dry mouth
  • earache
  • eye redness
  • false or unusual sense of well-being
  • feeling of unreality
  • feeling sad or empty
  • frequent bowel movements
  • frequent urge to urinate
  • headache
  • hearing loss
  • heartburn
  • hives or welts
  • itching ears
  • joint pain
  • lack of appetite
  • lack of feeling or emotion
  • lack or loss of self-control
  • lack or loss of strength
  • longer or heavier menstrual periods
  • loss of balance
  • loss of interest or pleasure
  • memory problems
  • mood swings
  • muscle aches, cramping, pain, or stiffness
  • nausea
  • nightmares or unusual dreams
  • redness of the skin
  • redness or soreness of the throat
  • sense of detachment from self or body
  • slowing of mental and physical activity
  • sneezing
  • stuffy or runny nose
  • swollen joints
  • tiredness
  • trouble concentrating
  • vision changes
  • vomiting

For Healthcare Professionals

Nervous system

  • Very common (10% or more): Headache (up to 19%), somnolence/drowsiness (up to 15%), dizziness (up to 12%)
  • Common (1% to 10%): Lethargy, lightheadedness, ataxia, vertigo, labyrinthitis, balance disorder, attention disturbance, hypoesthesia, ataxia, burning sensation, paresthesia, postural dizziness, tremor
  • Uncommon (0.1% to 1%): Syncope, cerebrovascular disorder, dysarthria, migraine, speech disorder, stupor, dysphagia, dysgeusia
  • Rare (less than 0.1%): Restless legs, rigors, abnormal gait, hypokinesia, hypotonia, neuralgia, neuritis, neuropathy, paresis, depressed level of consciousness

Cardiovascular

  • Common (1% to 10%): Palpitations, increased blood pressure
  • Uncommon (0.1% to 1%): Postural hypotension, hypertension, tachycardia, increased heart rate
  • Rare (less than 0.1%): Flushing, hypotension, hot flashes, angina pectoris, arrhythmia, arteritis, circulatory failure, extrasystoles, aggravated hypertension, myocardial infarction, phlebitis, varicose veins, ventricular tachycardia

Dermatologic

  • Common (1% to 10%): Rash, urticaria, skin wrinkling
  • Uncommon (0.1% to 1%): Increased sweating/hyperhidrosis, pruritus, contact dermatitis
  • Rare (less than 0.1%): Acne, bullous eruption, dermatitis, furunculosis, photosensitivity reaction, angioneurotic edema

Gastrointestinal

  • Common (1% to 10%): Diarrhea, dry mouth, abdominal pain, constipation, dyspepsia, hiccup, nausea, vomiting, gastroenteritis, abdominal discomfort, abdominal tenderness, frequent bowel movements, gastroesophageal reflux disease, flatulence
  • Rare (less than 0.1%): Altered saliva, increased saliva, tenesmus, enteritis, eructation, esophagospasm, gastritis, hemorrhoids, intestinal obstruction, rectal hemorrhage, tooth caries

Genitourinary

  • Common (1% to 10%): Urinary tract infection, menorrhagia, dysuria, vulvovaginal dryness
  • Uncommon (0.1% to 1%): Menstrual disorder, vaginitis, cystitis, urinary incontinence, dysmenorrhea
  • Rare (less than 0.1%): Breast fibroadenosis, breast neoplasm, breast pain, micturition frequency, nocturia, polyuria, pyelonephritis, urinary retention

Hypersensitivity

  • Common (1% to 10%): Allergy
  • Rare (less than 0.1%): Allergic reaction, aggravated allergy, anaphylactic shock
  • Frequency not reported: Angioedema, anaphylaxis

Metabolic

  • Common (1% to 10%): Appetite disorder
  • Uncommon (0.1% to 1%): Anorexia, hyperglycemia, thirst
  • Rare (less than 0.1%): Decreased weight, increased appetite, gout, hypercholesteremia, hyperlipidemia, increased alkaline phosphatase, increased BUN

Musculoskeletal

  • Common (1% to 10%): Back pain, arthralgia, myalgia, neck pain, muscle cramp
  • Uncommon (0.1% to 1%): Leg cramps, arthritis, muscle spasms, involuntary muscle contraction
  • Rare (less than 0.1%): Tetany, arthrosis, muscular weakness, sciatica, tendinitis

Ocular

  • Common (1% to 10%): Diplopia, abnormal vision, visual disturbance, eye redness, blurred vision, altered visual depth perception, asthenopia
  • Uncommon (0.1% to 1%): Eye irritation, eye pain, scleritis
  • Rare (less than 0.1%): Abnormal accommodation, glaucoma, periorbital edema, conjunctivitis, corneal ulceration, abnormal lacrimation, parosmia, photopsia

Other

  • Common (1% to 10%): Influenza-like symptoms, chest pain, chest discomfort, asthenia, fatigue, tinnitus, contusion, increased body temperature, otitis externa, pyrexia/fever, neck injury, infection
  • Uncommon (0.1% to 1%): Pallor, pain, edema, falling, malaise, trauma, taste perversion
  • Rare (less than 0.1%): Face edema, pain, increased drug tolerance, otitis media, falls, Abscess herpes simplex/herpes zoster
  • Frequency not reported: Injuries (e.g., hip fractures, intracranial hemorrhages)

Psychiatric

  • Common (1% to 10%): Depression, abnormal dreams, sleep disorder, insomnia, exacerbated/aggravated insomnia, hallucinations, agitation, nightmare, drugged feeling, confusion, euphoria, memory impairment, amnesia, anterograde amnesia, nervousness, disorientation, anxiety, psychomotor retardation, binge eating, depersonalization, disinhibition, mood swings, stress symptoms, apathy
  • Uncommon (0.1% to 1%): Decreased cognition, detached, difficulty concentrating, emotional lability, illusion, sleeping (after daytime dosing), irritability, drunk feeling, reduced alertness
  • Rare (less than 0.1%): Impotence, abnormal thinking, aggressive reaction, decreased libido, delusion, dementia, feeling strange, hysteria, intoxicated feeling, manic reaction, panic attacks, personality disorder, somnambulism, suicide attempts, neurosis, perceptual disturbances, restlessness, libido disorder, rages, inappropriate behavior
  • Frequency not reported: Psychoses, dependence
  • Postmarketing reports: Anger, abnormal behavior

Respiratory

  • Common (1% to 10%): Sinusitis, pharyngitis, upper respiratory infection, lower respiratory infection, throat irritation, nasopharyngitis, dry throat, rhinitis
  • Uncommon (0.1% to 1%): Bronchitis, coughing, dyspnea
  • Rare (less than 0.1%): Pulmonary embolism, pulmonary edema, yawning, bronchospasm, respiratory depression, epistaxis, hypoxia, laryngitis, pneumonia

Hepatic

  • Uncommon (0.1% to 1%): Abnormal hepatic function, increased ALT/SGPT
  • Rare (less than 0.1%): Bilirubinemia, increased AST/SGOT
  • Postmarketing reports: Acute hepatocellular, cholestatic, or mixed liver injury with or without jaundice

Hematologic

  • Rare (less than 0.1%): Increased erythrocyte sedimentation rate (ESR), anemia, hyperhemoglobinemia, leukopenia, lymphadenopathy, macrocytic anemia, purpura, thrombosis

Renal

  • Rare (less than 0.1%): Acute renal failure, renal pain

Local

  • Postmarketing reports: Sublingual application site reactions (e.g., oral ulcers, blisters, mucosal inflammation)

The Drug of Choice 



Written for FANDANGO’S ONE WORD CHALLENGE: TRIAL.   I have been having problems finding something of meaning to create an answer for the prompts this year. So I decided to strengthen and tighten my focus. My chosen topics are as follows:  (Monday) Life in Retirement; (Tuesday) Hobbies: Archaeology and Astronomy; (Wednesday) Fitness; (Thursday) Chores; (Friday) Writing; (Saturday) Hobbies: Music and Photography; and (Sunday) Hobbies: Gardening and Birdwatching.

One thought on “DRUG TRIALS

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